An ancient prophecy foretells a planetary alignment and the coming apocalypse. Lazzaro Corsetti, a Roman exorcist cursed with immortality after imprisoning a fallen angel within himself, has waited three centuries for destiny to unfold. Today he finds Gabriel, a young Irish seminarian, the last descendant of Samael and the only one capable of facing Asmodeus, the most powerful of demons. As Lazzaro trains Gabriel for his destiny, dark forces rise: Lamia builds an army of corrupted souls and Lilith returns, wearing the face of the woman Lazzaro once loved. The final battle between faith and darkness begins.